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Differences in sequence and structure of these variable regions were shown to be important in determining substrate specificity towards various Ub or Ubl chains and Ub chains connected by various linkage types (Supplementary Fig

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doi:10.1002/tox.21795 Wang F, Li C, Liu W, Jin Y (2013) Oxidative damage and genotoxic effect in mice caused by sub-chronic exposure to low-dose volatile organic compounds

2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Supplementary Table S1