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A recent Nature publication further showed that a bimodal molecule combining GLP-1 receptor agonism with NMDA receptor antagonism could reverse obesity and hyperglycaemia in rodent models, with targeted effects on hypothalamic and brainstem neuroplasticity (Petersen et al., 2024, DOI)

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doi: 10.1007/s40265-015-0410-1

Introduction: Direct vs Indirect IGF-1 Pathway Activation Two fundamentally distinct approaches to IGF-1 pathway research have emerged: direct exogenous IGF-1 administration (IGF-1 LR3) and indirect stimulation through growth hormone (HGH), which promotes hepatic IGF-1 synthesis

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