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Mice with more fat had more NNMT

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Demonstrated Safety and Tolerability Profile 1 With RADICAVA , the most common adverse reactions were contusion, gait disturbance, and headache 1, a (see footnote) Safety profile was demonstrated in pooled placebo-controlled trials b (see footnote) in which 184 patients with ALS were administered RADICAVA (edaravone) (60 mg) in 24-week treatment cycles

And, they can walk extended distances with the addition of cane or something to lean on

Progress in Brain Research, 185 , 105-129