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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

Swallow the tablet whole with a small drink of water

In the Phase 2 trial, the titration schedule for the 12 mg group looked roughly like this: Weeks 14 at 2 mg, weeks 58 at 4 mg, weeks 912 at 6 mg, weeks 1316 at 8 mg, then 12 mg from week 17 onward

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While much remains to be discovered about optimal combination strategies, the foundation of knowledge continues to grow