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Stimulation of these receptors, expressed in a wide range of tissues, including the pancreas, liver, gastrointestinal tract, kidneys, heart, endothelium, muscles, and brain, mediate multiple effects on the body

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Duration matters significantly: short-term prednisone courses (less than 2-4 weeks) cause minimal metabolic disruption to your GLP-1 progress, whereas long-term prednisone therapy (months or years) for conditions like lupus, rheumatoid arthritis, or chronic obstructive pulmonary disease creates sustained metabolic challenges