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Furthermore, escalated oxidative stress can activate GSK3 [90], contributing to elevated A levels [60] (see Section Unlocking Melatonins Anti-Amyloidogenic Potential ) and hyperphosphorylation of the microtubule-associated protein tau [91, 92] (see Melatonins Potential to Counteract Tau Pathology )

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Approved population matters Evidence from HIV-associated lipodystrophy cannot automatically be generalized to healthy adults, obesity, bodybuilding, or age-related body-composition changes

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