The 8mg dose achieves approximately 94% of the weight effect and 99% of the liver fat effect seen at 12mg, but with meaningfully fewer side effects
The combination can produce weight losses of 150, 200 pounds numbers that were really unachievable before. Theres also one practical argument for surgery that doesnt get much attention: permanence
Gastrointestinal adverse events were the most common side effects and were generally mild to moderate
Specifically, they proposed an approach in which GLP-1RAs could be prescribed for an initial period of weight loss before patients transitioned to cheaper alternative interventions for weight maintenance such as lower-cost medications, behavioral health programs and support from nutritionists
For example, a patient in a 24% federal tax bracket purchasing semaglutide injection at $189/mo (or $149/mo on the 6-month plan) saves approximately $36 monthly using an HSA compared to paying with after-tax dollars
Make it 2,000 calories: Add 1 cup low-fat plain kefir to breakfast, substitute 1 serving Guacamole Chopped Salad for the Spicy Cabbage Slaw at dinner and add cup unsalted dry-roasted almonds to evening snack