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Most patients notice reduced hunger or food cravings within 35 days, though visible weight loss typically appears after 24 weeks of consistent dosing

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Since starting semaglutide, Ive noticed that I have a lot less bloat and my weight has been very stable with almost no fluctuations

MHRA Updated Guidance for Semaglutide Prescribers and Patients (GOV.UK, February 2026) 3

Other options: Some doctors may also consider medications like orlistat or naltrexone/bupropion (Contrave), depending on your health needs

Unlike the brand-name shortage, compounded semaglutide supply from multiple 503A pharmacies has remained more resilient because it does not depend on a single manufacturer