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Combination cardiometabolic therapy in type 2 diabetes: optimizing SGLT2 inhibitor and GLP1 receptor agonist use

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More specifically, caffeic acid decreased Keap1 expression, activated Nrf2 by inhibiting the binding of Keap1 to Nrf2, and thus upregulated the expression of HO-1 and NQO1

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doi: 10.2337/diabetes.52.1.124

These muscle fiber types differ significantly in their myosin heavy chain (MyHC) isoform composition, oxidative metabolic capacity, and ATP production efficiency (Bassel-Duby & Olson, 2006)