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60 The Km of the human NNMT enzyme for NAM (approximately 430 M) is much higher than the affinity of NAMPT for NAM ( 0.1 mM in mammalian plasma, which can only be used by spleen, small intestine, pancreas, kidney and liver

Allerdings gibt es stichpunktartige Hinweise auf einen Zusammenhang

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Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression