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In fact, TIGAR redirects glucose-6-P toward the pentose phosphate pathway helping to lower ROS by the NADPH-dependent antioxidant systems

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Concurrently, it degrades host Gpx4 through lysosome-mediated autophagy

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Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits