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GLP-1 medications are eliminated through renal pathways, and reduced kidney function affects both drug tolerance and the risk of complications particularly dehydration-related acute kidney injury, which can occur when GI side effects (nausea, vomiting) reduce fluid intake

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When the hormone or the receptor agonist binds to it, a series of cascade effects occur, eventually leading to the release of Ca2+

3 Thus, the significant weight loss and metabolic benefits of GLP-1 RAs are partly due to neurological mechanisms that may have therapeutic implications beyond weight loss and diabetes management