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Worsening of diabetic retinopathy: Rapid improvement in blood glucose control has been associated with transient worsening of diabetic retinopathy in people with pre-existing retinopathy

No clinical trial has tested the exact combination, but the closely related CagriSema (cagrilintide + semaglutide) Phase 3 trial showed that adding amylin to a GLP-1 backbone improves weight loss

To learn more, please see a recent article from The New York Times that featured our study findings

2) GLP-1s for weight loss Interestingly, the lasting effect of GLP-1s to support type 2 diabetes might be its impact on reducing appetite and supporting weight loss than the impact it has on the pancreas

Holst, Wewer Albrechtsen, Gabe, Rosenkilde)

GLP-1 receptor agonists bind to and activate GLP-1 receptors located throughout the body, particularly in pancreatic beta cells, the gastrointestinal tract, and the central nervous system