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More recently, a 2011 trial involving more than 35,500 men over 50 found that large doses of vitamin E increased the risk of prostate cancer by 17 percent

Rare but serious risks include pancreatitis (requiring immediate medical attention if severe abdominal pain occurs), gallbladder disease, and potential thyroid C-cell tumors (based on rodent studies)

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This dual expression facilitates not only direct tumor cell lysis but also the induction of robust immunogenic cell death, characterized by the release of pro-inflammatory cytokines and DAMPs that enhance dendritic cell activation and T cell priming (202)