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A larger phase IIb trial of intranasal glutathione (300 mg/dose, three times daily for 3 months, n=45) also showed no significant improvement over placebo (Mischley et al., J Parkinsons Dis, 2017) [52]

Reduction of oxidative stressinduced hyperpigmentation Oxidative stress from UV exposure, pollution, and inflammation can stimulate melanocytes and trigger excess melanin production, leading to dark spots and uneven tone

Family variant testing, using Sanger sequencing, detected the same BBOX1 variants as in her brother, who also was found to have elevated plasma -BB levels (Table 1)

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Results may vary depending on individual skin type and concerns