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From the abstract: Semaglutide showed robust therapeutic effects in treatment-seeking participants with obesity and alcohol use disorder and this trial supports previous preclinical and clinical findings suggesting GLP-1 receptor agonists as a potential novel treatment target for alcohol use disorder. Always a challenge with such big placebo effects in alcohol trials, and this trial provided real-human CBT to the placebo and semaglutide groups

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IL-1 is a typical inflammatory mediator produced by nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome, leading to myocardial hypertrophy, heart failure, and coronary atherosclerosis [85, 86]

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Oral GLP1 agonist, update on how to use+benefit Effects of Semaglutide on CKD in patients with T2DM-1.pptx Empagliflozin glycemic control and beyond-Dr Shahjada Selim Cardiovascular safety of anti-diabetic drugs.Cardiovascular Outcome Trials