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Unlike MC4R-targeted agonists such as setmelanotide, whose efficacy is intrinsically limited by the functional status of the impaired receptor, GLP-1 RAs operate via pathways largely independent of the leptin-melanocortin circuitry

Phase 3 Progress and Trial Sites in the UK The UK is playing a central role in the TRIUMPH programme, with several academic centers and primary care research sites actively participating in the trials

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