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For influenza virus, the ability of HA stem-targeting nAbs to induce ADCC but their rather weak neutralizing activity compared with nAbs to the HA head domain, which have weak interaction as immune complexes with FcRs but potent neutralizing activity, probably explains the dependence of anti-stem nAbs (but not anti-head nAbs) on Fc-dependent effector functions for protective efficacy 173

255 Although HIV mainly infects and affects microglia, infected astrocytes show decreased homoeostatic capacity

Dec 2016;62(6):387-395

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New England Journal of Medicine Jastreboff AM, et al