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Clinical trials show GLP-1 receptor agonists reduce waist circumference by approximately 13.5 cm with semaglutide after 68 weeks, with imaging studies demonstrating significant decreases in visceral adipose tissue volume

The SEMALEAN trial found lean mass declined then stabilised while handgrip strength improved by 4.5 kg and sarcopenic obesity prevalence fell from 49% to 33% over twelve months

Sirohi, S., Schurdak, J

Blum, are going beyond the scale and leaning more heavily into the potential healthspan and longevity benefits

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