Mhle L, Mattei D, Heimesaat MM, Bereswill S, Fischer A, Alutis M, et al
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The AUGUSTUS trial (N=4,614) showed that adding aspirin to apixaban in patients with atrial fibrillation and recent acute coronary syndrome increased bleeding events from 7.3% to 10.9% over 6 months (HR 1.89 to 95% CI 1.59 to 2.24) [12]
The biological footprint of GHK-Cu in the published research includes copper-dependent extracellular matrix processes (notably through the copper-dependent enzyme lysyl oxidase, which cross-links collagen and elastin), broad effects on gene expression characterized in transcriptomic studies, antioxidant and redox-related effects connected to copper biochemistry, effects in wound-healing and tissue-repair research models, and effects in hair follicle biology research