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important nuance with the "glp-1 causes lean mass loss" debate: dexa scans are the tools we most commonly use to assess body composition, and they cannot distinguish actual muscle tissue loss from intramuscular fat loss (fat that surrounds the muscle)

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Because of this precision, they tend to have: High specificity for their targets Shorter halflives (they are broken down relatively quickly) Typically lower immunogenicity (less likely to provoke immune reactions) than larger biologic drugs

Methionine, choline, and inositol facilitate hepatic VLDL assembly

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(visit source) Harrison FE, May JM