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These represent two hypothetical and simplistic extremes of a broad spectrum of intermediate phenotypes acquired by these cells, under the influence of the microenvironment ( Macrophage On and Off-Targets and Responses It has been shown that GPER and ER do not mediate the off-target macrophage responses to tamoxifen, since macrophages do not express ER and GPER-selective activation elicits different responses as those induced by tamoxifen

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6 Employers and government agencies are weighing whether to broaden coverage