Tirzepatide: Mounjaro and Zepbound Tirzepatide is the only dual GLP-1/GIP agonist on this list of GLP-1 medications, and the most potent currently approved
How to Integrate This Stack Into a Cutting Protocol Supplementation alone does not create fat loss a sustained caloric deficit relative to your total daily energy expenditure is the non-negotiable foundation
Higher NAD enhances SIRT1 activity, promoting fat oxidation and mitochondrial remodeling via PGC-1 pathwaysmechanisms consistent with improved endurance and recovery potential (Cant et al., Cell Metabolism
Reconstitution planning Rather than reconstituting all peptides simultaneously, stagger reconstitution based on usage rates
However, injection carries its own risks (infection, sterility, injection site reactions)
"For a patient who needs to achieve more weight loss and who doesn't experience many side effects, perhaps this higher dose will help them achieve it," she says