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Longterm effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate ( Macaca mulatta )

Meesters, M

Top-line outcomes at the 48-week primary endpoint, by dose: Notable Phase 2 finding particularly relevant to the 10mg vial: the 1mg/week cohort still produced 8.7% mean weight loss over 48 weeks, clinically meaningful activity even at sub-therapeutic doses relative to the 12mg maximum

The new drugs, which were originally developed to treat diabetes, are targeting the biology that makes weight so hard to lose and keep off: They dial down hunger in the brain, slow gastric emptying, and improve post-meal insulin signaling

E.HalarisA.IqbalO.HoppensteadtD.FareedJ.ZhuH.et al

It reduces the risk of heart disease, improves lipid profiles, and exerts anti-inflammatory effects, offering comprehensive cardiovascular protection