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They are pathway-level markers that do not predict response to any specific compound, yet they describe the system a clinician prescribes into

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Serum retinol alone is a poor indicator: it stays normal until liver stores are almost depleted, and it falls in inflammation even when stores are adequate

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Early clinical and preclinical data suggest benefits also in rheumatoid arthritis, osteoarthritis, osteoporosis, psoriasis, and hidradenitis suppurativa

Demetallation of CuHSA complex in the presence of His was also studied