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Identifying these mutations enables the clinician to target patients to prescribe antioxidant protection regimes or chemotherapy regimens that will overcome these genetic defects [17]

Meister 1988

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Different clinical symptoms reported in individual patients with 5-oxoprolinase deficiency are renal stone formation, enterocolitis, mental retardation, neonatal hypoglycemia, microcytic anemia and microcephaly [4045]

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Mild gastrointestinal effects flatulence, loose stools are occasionally reported and typically self-resolve