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The imbalance of G T and G D populations (or GTP and GDP) caused by the GEF activity-mediated exchange is restored by regulators of G protein-signaling (RGS) displaying GTPase activating protein (GAP) activity that converts G T back to G D via GTP hydrolysis

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R., Tran, K., Reddy, S

[35] In rodent pre-clinical studies, urinary and serum alpha GST have been shown to be sensitive and specific indicators of renal proximal tubular and hepatocyte necrosis respectively

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