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However, results are heterogeneous and strain-specific

Methods: An expert working group (EWG) comprising ten pulmonologists and a multidisciplinary drafting committee reviewed data from in vitro , mechanistic, animal and observational studies, randomized trials, reviews and meta-analyses for role of NAC in respiratory diseases

Its small size confers favorable physicochemical properties for solubility, stability, and intranasal or subcutaneous delivery, but also raises questions about specificity that are common to short peptides in vivo proteolytic stability, off-target binding, and minimum receptor recognition motif identification all require additional characterization that the published literature does not yet fully provide

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