To detect potential sources of heterogeneity, subgroup analyses were performed according to the predefined variables, including duration of the intervention, NAC dosage, study location and the type of control
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Rather than defaulting to patch testing due to the aforementioned limitations, clinicians should consider whether other factorssuch as individual history, disease chronicity, symptom severity, and response to initial treatmentmay be better determinants of a management strategy [57]
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