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118 Furthermore, cerebral hyperinsulinemia is associated with diminished clearance of A peptides due to the competitive inhibition of insulin-degrading enzyme, a metalloprotease responsible for degrading both insulin and A, which preferentially binds insulin over A under hyperinsulinemic conditions

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10.1089/jmf.2016.0063 102 VatsyayanR.ChaudharyP.SharmaA.SharmaR.Rao LelsaniP