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J Pept Sci 14:588595

Reference: 18.a9643017.1785208463.a6e7fbcb

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Different GLP-1 receptor agonists have varying pharmacokinetic profiles and receptor binding characteristics

While some studies have found a beneficial effect, not all have

By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion