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Fourth Step: N ormalization Hepcidin, a peptide hormone synthesized in the liver, plays a central role in iron homeostasis by regulating ferroportin expression

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Emerging evidence further indicates that MTs particularly MT1 and MT2A constitute a critical cytoplasmic defense layer against cuproptosis by acting as effective copper sponges that sequester excess Cu + and restrict its aberrant interaction with mitochondrial targets 170,173,174

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Of these, 567 participants were patch tested with the standard series (TRUE-test)