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Patients should: Weigh themselves at the same time daily (particularly important for those with or at risk for heart failure), reporting sudden gains of 2-3 pounds overnight or 5 pounds within a week Note any new or worsening swelling in the legs, ankles, or abdomen Track blood pressure regularly, as hypertension often accompanies fluid retention Maintain a symptom diary including shortness of breath or reduced exercise tolerance Lifestyle modifications support healthy fluid balance

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People who are at high risk for cardiovascular disease, which is more common in those with diabetes, may also benefit from tirzepatide, as better blood sugar control can reduce the risk of heart problems

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Use 1 to 2% concentrations rather than chasing the highest number