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Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes
Specifically, we do not know what component of GLP-1 effects is attributable not to risk factor modulation, but rather to processes acting directly on the heart
The medicines in this family include liraglutide, semaglutide, and dulaglutide
However, in comparison to vehicle-treated mice, mice treated with GLP-1MK-801 demonstrated a slight decrease in plasma glucagon levels (Extended Data Fig
Some researchers find the larger injection volumes less comfortable, especially for daily protocols, though retatrutide is administered weekly which makes this less of a concern