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In small double-blind crossover trials at a single UK centre, an intravenous kisspeptin-54 infusion modulated sexual brain-processing networks on fMRI and increased penile tumescence by up to 56% versus placebo in men with HSDD (Mills et al., JAMA Netw Open 2023), with parallel brain-processing findings reported in women with HSDD (Thurston et al., 2022) and in healthy men (Comninos et al., 2017)

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GRX-SG is then reduced in the presence of GSH, GR and NADPH

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CagriSema is the only one with Phase 3 combo data and a pending FDA decision