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Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimers disease

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Local injection is less critical for TB-500 than for BPC-157

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VPA-exposed rats spent significantly less time in the target quadrant compared to controls ( P 0.05 )

Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains