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The decisive nuance, however, lies in the correction: once BMC was normalised to the gain in body weight, the apparent advantage disappeared, and volumetric cortical bone mineral density (BMD) remained unchanged

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In the randomised trials, the average effects are real but moderate, and they come with a ketone signal that has to be respected.6 When these medicines cut insulin need quickly, insulin must be reduced proactively or hypoglycaemia follows

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