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"These pharma companies have to decide which is more important to them, very high premiums or very high costs

Tirzepatide is typically administered as a subcutaneous injection once a week

The effect on stroke is remarkable (and was significant in the trials of both semaglutide and dulaglutide), amounting to an 18% risk reduction, also because the other class of new antidiabetic agents with cardiovascular benefits, the SGLT2-inhibitors, show no a similar effect on stroke (but do have a significant effect on heart failure) [24]

Patent expiries are creating opportunities for generics

Faster escalation means reaching the effective dose sooner but potentially dealing with more intense gastrointestinal side effects