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Notable for: Multi-database design (improves generalizability) Active comparator framework Emphasis on short-term safety with acknowledgment of need for longer follow-up Diabetes Care Retrospective Cohort Evaluated thyroid tumors (broader outcome than confirmed malignancies) and found no increased risk with GLP-1 RA exposure in type 2 diabetes patients initiating second-line treatments

No lethal dose was identified across a wide dose range from 0.006 mg/kg to 20 mg/kg body weight

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Third-party testing by organizations like HASTA, Informed Sport, or NSF provides additional verification that the product contains what it claims and doesnt contain contaminants

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial