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Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial

doi: 10.1128/CMR.00338-20 107

No validated human protocols exist

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P21 showed no adverse effects in studies lasting up to 12 months

Zepbound uses a dual mechanism involving two hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), to achieve greater weight loss than single-hormone therapies