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Other Drugs That Affect Vitamin B12: The diabetes medicine Glucophage (metformin) can also lead to problems with vitamin B12

The tools with the strongest evidence for anxiety and mood support include consistent sleep (seven-plus hours, regular schedule), regular physical activity (both resistance training and cardiovascular exercise have demonstrated antidepressant and anxiolytic effects), therapy or coaching for cognitive and behavioral patterns, mindfulness or stress-management practices, and social connection

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PMID 19116332

After that, they need a shot every month