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Furthermore, when we performed GSEA for each of the chondrocyte differentiation stages separately, we observed that among the three upregulated pathways, protein processing in ER was ranked highest in resting chondrocytes, but proteasome was top-ranked in columnar and ferroptosis in hypertrophic chondrocytes, suggesting that the phenotype progressively evolves during chondrocyte differentiation from a homeostatic adaptive response to cell death (Extended Data Fig

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The prevalence of metabolic syndromea cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and impaired glucose metabolismappears higher in individuals with hypothyroidism compared to the general population