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[71] A separate trial in women undergoing in vitro fertilization found that oral SOD supplementation increased serum catalase activity over 12 weeks compared to baseline, suggesting improvement in antioxidant defense

383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)

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