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Common early effects include: Reduced hunger between meals Smaller portion sizes feel satisfying Fewer cravings for high-calorie or high-sugar foods A noticeable quieting of intrusive thoughts about food Visible weight loss takes longer

Medication use requires medical supervision and ongoing lifestyle support

Similar movement was also seen for the C-terminal half of tirzepatide (2.1 measured by the C of I27 P )

Martin KW, Ernst E

Psychoneuroendocrinology (2012) 37(11):188595

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