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A recombinant human glucagon-like peptide (GLP)-1albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis

JAMA Netw Open 7, e2423385 (2024)

It binds to the GLP-1R, stimulating insulin secretion, suppressing glucagon release, delaying gastric emptying, and promoting satiety

A., Marinelli, C., Bettarini, C., Del Vescovo, G

marketed as Mounjaro for T2DM and Zepbound for obesity), is a 39-amino acid peptide acylated with a C20:0 fatty diacid moiety to lysine residue at position 20 with a molecular weight of 4.8 kDa [ Figure 2 , Table 1 ]

Customers reported their weight on their initial medical intake questionnaire and every 3 to 4 weeks thereafter