mechanism of action for glp 1 receptor agonists

mechanism of action for glp 1 receptor agonists GLP-1 as Treatments Type 2 Diabetes The Impact of GLP-1 Receptor

Name: mechanism of action for glp 1 receptor agonists GLP-1 as Treatments Type 2 Diabetes The Impact of GLP-1 Receptor
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Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC, and Upson BM (1998)

The mechanism involves the binding of NO to iron ions on soluble guanylate cyclase (sGC) located in the cytoplasm, leading to a conformational change in guanylate cyclase that enhances its bioactivity

If not adequately repaired, such damage can lead to cell death, DNA mutations, and genomic instability, exacerbating kidney dysfunction (94)