Per-Batch HPLC + Disulfide Bond Verification Because the lipolytic conformation depends on an intact Cys7-Cys14 disulfide bond, every released lot is checked both by HPLC for peptide purity and by non-reducing LC-MS or Ellman's reagent analysis for disulfide bond integrity
In lyophilized form, the peptide should be stored at -20C (optimal) or 2-8C (short-term), protected from light and moisture
For an intramuscular (IM) injection, the usual choice is a 22 to 25 gauge needle, 1 to 1.5 inches long
Never recap and throw needles in regular trash
Nonetheless, a meta-analysis of the Chinese population concluded that patients diagnosed with MS and relapsing MS had lower serum B12 levels than controls, whereas remitting patients did not exhibit this difference [131]
Weight loss may begin but is typically modest the priority at this stage is tolerability and establishing the habit of weekly injections