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In lab and clinical research, its been observed to activate fibroblasts (the cells that produce collagen), increase glycosaminoglycan synthesis (which helps skin retain water), modulate matrix metalloproteinases (MMPs, the enzymes that break down old tissue), and act as a copper cofactor in antioxidant pathways

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Khalili-FomeshiMAziziMGEsmaeiliMRGolMKazemiSAshrafpourMet al

Median follow up was 8.8 years, during which Lhteenvuo and colleagues found that 133,210 individuals (58.5%) were hospitalized for AUD at least once, and 138,390 individuals were hospitalized for any SUD

Interestingly, fluoxetine can cause either weight loss or weight gain in different individuals, though weight loss is more commonly observed initially