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Notably, the hydrolysis of glutamine steered by Glutaminase 1 (GLS1) is anomalously proactive in both psoriasis-afflicted individuals and analogous mouse models

Consistent with the mass spectrometric data, H3K36 dimethylation was elevated in DIO mouse livers, whereas Metformin treatment can significantly decrease histone H3K36 dimethylation in DIO mice to a level close to that of the chow-fed control mice