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Drug-drug interactions Besides Tac, cytochrome P450 enzymes CYP3A4/5 metabolize a broad spectrum of different drugs, which can also act as inducers or inhibitors and thus influence Tac metabolism (8890)

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They also interact with certain pain medications and can worsen post-operative nausea

We fused a signal peptide (SP) and a furin-cleavable sequence (FCS) to the upstream region of the Exe4 gene to enable Exe4 secretion from the edited liver

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